A Drug That Restores Memory in Mice!

November was a difficult month, what with the deaths of people I cared about, some revelations I wasn’t real happy to get, and the things that are relentlessly going on in the world. So I set myself a challenge.

In December, I will write three blog posts about things that make me hopeful and happy. I am also going to spend ten minutes a day making a little corner of my home prettier. In November, if I were in a relatively good mood, I would have said cleaner, or less cluttered. If I were in a bad mood, I would have said less ugly. And if I were in a terrible mood, I would have said a little less hideous. No more! Three weeks of prettiness, not one day of less hideousness. 

Since smiling is supposed to release feel-good hormones, I will smile whenever I remember to, whether I feel like it or not. We’ll see if it makes any difference!

Today’s beautifying project is to put away the clean dishes and put the dirty ones in the dishwasher. If that doesn’t take the full ten minutes, I shall wash two frying pans.

On to the blog post!


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I came across this article:

“Drug Reverses Age-Related Cognitive Decline within Days.” https://medicalxpress.com/news/2020-12-drug-reverses-age-related-cognitive-decline.html

It is a summary of “Small Molecule Cognitive Enhancer Reverses Age-Related Memory Decline in Mice.” by Karen Krukowski et al., eLife https://elifesciences.org/articles/62048

Now mind you, this study was done on mice, not humans. Still, mice are similar enough to humans to make this research terribly exciting. 

There is a quality control mechanism that shuts down the protein-forming ability of cells infected with a virus or containing a cancer-inducing mutation. This substance is called “integrated stress response” (ISR), and the substance that blocks ISB is called ISRIB, which stands for ISR InhiBitor. Blocking the production of protein is great until the virus is cleared or the cell with the mutation dies. If the mechanism is stuck in the working position, cells become dysfunctional.

Back to the mice.

About five years ago, the researchers had given ISRIB to mice with traumatic brain injuries. After a few days, the mice regained normal brain function! They were back to running mazes like healthy mice instead of stumbling around. making the same mistakes over and over again or quitting altogether.

The symptoms of traumatic brain injury look very much like the symptoms of normal aging. So why not give ISRIB to a group of aged mice matched with a group that didn’t receive ISRIB? Guess what? The ISRIB group did as well as young mice after one or two days. Three weeks later, they gave both groups a new challenge. Guess what? The ISRIB group still acted like young mice! And the group that didn’t get ISRIB still acted like old mice.

The researchers were getting really excited. They had already studied the effects of ISRIB in the restoration of memory function months after traumatic brain injury, the reversal of cognitive impairments in Down Syndrome, the reversal of noise-related hearing loss, fighting certain types of prostate cancer, and even enhancing cognition in healthy animals. They came up with a list of additional conditions that might respond to ISRIB. It included Alzheimer’s, ALS, MS, Parkinson’s, Mad Cow Disease, and, of course, age-related cognitive decline.

They didn’t limit their studies to neurons. The immune system shows the same kind of age-related dysfunction as the brain does. It turns out that ISRIB resets T-cells the same way it resets neurons. These days we need every T-cell we can get our hands on!

I’m also getting excited about things that are not on their list – namely, all the little quirks of cognition and memory associated with dissociation. Could ISRIB help with the rapid fading of memories, the lack of memories of childhood, the lack of memories of traumatic events, and the inability to recall names, faces, or dates? How about anxiety, depression, flashbacks, and nightmares? How about memory-sharing between alters? My mind is spinning with exciting ideas!

ISRIB sure sounds like a miracle drug to me. I’m aware that it probably won’t be available for human trials in my lifetime. If it is, I’ll be the first to volunteer. I bet, though that it will be available to my children and grandchildren. I know that some of those reading this post are younger than my children, perhaps even younger than my grandchildren. It makes me very happy to think that ISRIB may become available and may prove to be of benefit to you.


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Upcoming Holidays

December
Sundays of advent: 11/28, 12/5, 12/12, 12/19
12/14 New moon
12/14 Total solar eclipse. Totality will be visible in Chile and parts of Argentina. Partial eclipse will be visible in southern South America and south-east Africa. See https://www.timeanddate.com/eclipse/map/2020-december-14
12/21 Winter solstice/Yule/St. Thomas’ Day
12/24 Christmas Eve
12/25 Christmas Day
12/29 Full moon
12/31 New Year’s Eve

January
1/1 New Year’s Day
1/6 (?) Epiphany/Three Kings’ Day
1/7 St Winebald’s Day
1/13 New Moon
1/13 Satanic New Year
1/17 Feast of Fools/Old Twelfth Night/Satanic and demon revels
1/18 (?) Martin Luther King Jr. Day
1/20 (?) St. Agnes’ Eve
1/28 Full moon

February
2/2 Candlemas/Imbolc/Satanic Revels
2/11 New moon
2/14 Valentine’s Day
2/12 (?) Lincoln’s Birthday
2/15 (?) Presidents’ Day/Washington’s birthday
2/16 Shrove Tuesday/ Mardi Gras
2/17 Ash Wednesday/beginning of Lent
2/25 Walpurgis Day
2/27 Full Moon

Dates Important to Nazi and Neo-Nazi groups
11/29 -12/16 Chanukah/Hanukkah (Jewish Festival of Lights)
1/28 Tu Bishvat/Tu B’Shevat  (Jewish celebration of spring)
1/12 Birth of both Rosenberg and Goering, Nazi Leaders in WWII
1/30 Hitler named Chancellor of Germany
2/26 Purim (Deliverance of the Jewish people from Haman in Persia)
(NOTE: Not all groups meet on Jewish holidays. Some groups also mark Candlemas, Beltane, Lammas, Halloween, the solstices, and the equinoxes.)

 

* Remember my post on Pornhub?
https://ritualabuse.wordpress.com/2020/11/21/great-good-news-pornhub/


From The Associated Press: “Mastercard and Visa said … they would block their customers from using the credit cards to make purchases on Pornhub following accusations the pornographic website showed videos of child abuse and rape. Mastercard said it was also investigating other websites for potential illegal content.”

*And remember the one on unwanted reactions to meditation?
https://ritualabuse.wordpress.com/2020/10/21/ritual-abuse-survivors-and-meditation/


Here is a short video explaining why they happen and a couple of suggestions on preventing them.
https://vimeo.com/403330738

* You can find more information on the following holidays at:
Yule/Winter Solstice https://ritualabuse.wordpress.com/2012/12/15/yulewinter-solstice/
Candlemas https://ritualabuse.wordpress.com/2012/01/21/candlemas/
Valentine’s Day https://ritualabuse.wordpress.com/2016/02/10/valentines-day/
Spring Equinox https://ritualabuse.wordpress.com/2012/02/13/the-spring-equinox/
Easter: (personal) For background, see Spring Equinox https://ritualabuse.wordpress.com/2014/04/21/easter-blues/
Walpurgisnacht/May Eve: https://ritualabuse.wordpress.com/2017/04/20/walpurgisnacht/
Beltane: https://ritualabuse.wordpress.com/2013/04/28/beltane/
Mothers’ Day: https://ritualabuse.wordpress.com/2016/04/26/mothers-day/
Fathers’ Day: https://ritualabuse.wordpress.com/2020/06/20/ritual-abuse-and-fathers-day/
Summer Solstice (corrected text) https://ritualabuse.wordpress.com/2013/06/15/well-this-is-embarrassing/
Lammas https://ritualabuse.wordpress.com/category/lamas/
and https://ritualabuse.wordpress.com/2012/07/23/august-ritual-dates/
Feast of the Beast/Bride of Satan: Part 1 https://ritualabuse.wordpress.com/2013/08/31/the-feast-of-the-beast/
Feast of the Beast/Bride of Satan: Part 2 https://ritualabuse.wordpress.com/2017/03/20/feast-of-the-beast-part-ii/
Fall Equinox https://ritualabuse.wordpress.com/2012/09/16/the-fall-equinox/
Halloween (personal) https://ritualabuse.wordpress.com/2016/10/11/halloween/
Halloween (background) https://ritualabuse.wordpress.com/2011/10/02/samhainhalloween/
Thanksgiving https://ritualabuse.wordpress.com/2016/11/20/thanksgiving/

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* How to add a comment after a post This blog’s design makes it hard to figure out how to comment. Go down to the bottom of the post (after the calendar) You will see in light grey type: “RATE THIS” tagged (a list of the tags) (the number of) comments” Click on the word “comments” to open all posted comments.

At the very bottom of the page, you will see “LEAVE A REPLY.” That’s where you make a new comment. You can reply to a posted comment by clicking “Reply” under that comment. In each case, make sure to click “POST COMMENT” when you are finished. It’s a good idea to write out your comment first and then paste it in so that you don’t risk losing what you wrote.

Ritual Abuse Causes Early Physical Aging

* You can find more information on the following holidays at:

Feast of the Beast/Bride of Satan: Part 1: https://ritualabuse.wordpress.com/2013/08/31/the-feast-of-the-beast/
Feast of the Beast/Bride of Satan: Part 2: https://ritualabuse.wordpress.com/2017/03/20/feast-of-the-beast-part-ii/
Fall Equinox: https://ritualabuse.wordpress.com/2012/09/16/the-fall-equinox/
Halloween (personal): https://ritualabuse.wordpress.com/2016/10/11/halloween/
Halloween (background): https://ritualabuse.wordpress.com/2011/10/02/samhainhalloween/
Thanksgiving: https://ritualabuse.wordpress.com/2016/11/20/thanksgiving/
Yule/Winter Solstice: https://ritualabuse.wordpress.com/2012/12/15/yulewinter-solstice/
Candlemas: https://ritualabuse.wordpress.com/2012/01/21/candlemas/
Valentine’s Day: https://ritualabuse.wordpress.com/2016/02/10/valentines-day/
Spring Equinox: https://ritualabuse.wordpress.com/2012/02/13/the-spring-equinox/
Easter: personal (for background, see Spring Equinox): https://ritualabuse.wordpress.com/2014/04/21/easter-blues/
Walpurgisnacht/May Eve: https://ritualabuse.wordpress.com/2017/04/20/walpurgisnacht/
Beltane: https://ritualabuse.wordpress.com/2013/04/28/beltane/
Mothers’ Day: https://ritualabuse.wordpress.com/2016/04/26/mothers-day/
Fathers’ Day: https://ritualabuse.wordpress.com/2020/06/20/ritual-abuse-and-fathers-day/
Summer Solstice (corrected text): https://ritualabuse.wordpress.com/2013/06/15/well-this-is-embarrassing/
Lammas: https://ritualabuse.wordpress.com/category/lamas/
and Lammas: https://ritualabuse.wordpress.com/2012/07/23/august-ritual-dates/

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It seems that every couple of years, I read about another deleterious effect of abuse that shows up years after the actual abuse has stopped. Just last week, I got another opportunity to rant – or rather, to process my righteous anger –  about how ritual abuse ravages our bodies in so many different ways.

What set me off was an article in an email newsletter I get from Harvard. Apparently, childhood violence (but not neglect) sets processes in motion that make victims age faster. They aren’t talking about chronic diseases like lupus, arthritis of all sorts, diabetes, or addictions, all of which often shorten the life span significantly, This is on a cellular level!

Here’s the Harvard Gazette summary of: Colich, Natalie L., Rosen, Maya L., Williams, Eileen S., and McLaughlin, Katie A. “Biological Aging in Childhood and Adolescence Following Experiences of Threat and Deprivation: A Systematic Review and Meta-Analysis.” American Psychological Association, Psychological Bulletin, 8/3/2020 DOI: 10.1037/bul0000270: https://news.harvard.edu/gazette/story/2020/08/violence-and-trauma-in-childhood-accelerate-puberty/?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=Daily%20Gazette%2020200805%20(1) .

This appears to be the original article in its entirety; complete, interesting, very long, and very complex. https://www.apa.org/pubs/journals/releases/bul-bul0000270.pdf .

The authors found that violence in childhood causes early puberty. It also shortens telomeres, the part of the chromosome at the ends, which protects them from deterioration. Essentially, this means that chromosomes will wear out earlier.

I don’t really understand this part of early aging, so I’ll just quote from the article.

“Another area was epigenetic aging metrics, in which patterns of methylation across the genome can be used to estimate a person’s chronological age. Again, children who experienced violence showed accelerated epigenetic aging markers compared with their chronological age, indicating that their cells aged more quickly than expected.”

But that’s not all. In childhood, the outer parts of the brain thin, and the number of connections between the neurons diminishes. The brains of children living with violence thinned faster than those of the other children, especially in areas that process social situations and emotional information.

This means that the brain has adapted to being tuned in to situations that present a threat and is less focussed on situations that are not dangerous. No wonder, as adults, that we are hypervigilant and anxious and have trouble developing trusting relationships.

It’s just not fair. When you escape, you should be rewarded with a healthy body that doesn’t hurt, as well as a spirit full of hope and determination. Plus not just self-esteem, but pride at being able to get free of their clutches. I think this is the least you could ask for, the least you should expect.

Well, we all know it doesn’t work that way. Torture damages body, mind, and spirit, and you are left with the challenge of figuring out just what the damage is and what can be done about it. They made the mess, and you get the job of cleaning it up.

By you, I mean you and I and all survivors. Not a single one of us gets a fair shake. As I say when I am really furious, this sucks toad tits.

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Here’s a list of other blog entries on physical problems and ritual abuse:

Depression, Obesity, and Inflammation
https://ritualabuse.wordpress.com/2017/08/18/depression-obesity-and-inflammation/

PTSD and Dementia
https://ritualabuse.wordpress.com/2014/04/10/ptsd-and-dementia/

Things on My Mind This Week (Ritual Abuse Correlated with Ovarian Cancer)
https://ritualabuse.wordpress.com/2019/09/10/%e2%80%a8ritual-abuse-things-on-my-mind-this-week/

Stress, Cortisol, Eating, and Meditation
https://ritualabuse.wordpress.com/2014/07/30/stress-cortisol-eating-and-meditation/

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Upcoming Holidays

August
8/24 St. Bartholomew’s Day
September
9/1 Full moon
9/5 – 9/7 Feast of the Beast/Marriage of the Beast
9/7 Labor Day (United States)
9/22 Fall Equinox
9/29 Michaelmas/Feast of Archangel Michael and of all Angels
October
10/1 Full moon
10/12 Columbus Day (?)
10/13 Backward Halloween
10/31 Full moon (Blue Moon)
10/31 Halloween/start of Celtic New Year/start of the dark half of the year

Dates Important to Nazi and Neo-Nazi groups
10/4 Hitler’s alternate half birthday
10/20 Hitler’s half birthday
10/16 Death of Rosenburg
10/19 Death of Goering
10/31 Halloween
(NOTE: Not all groups meet on Jewish or Christian holidays. Some groups also mark Candlemas, Beltane, Lammas, Halloween, the solstices and the equinoxes.)

After the Triumph, the Crash

* Detailed instructions for making comments are in “News Items.”

* Summer Solstice – https://ritualabuse.wordpress.com/2013/06/14/the-summer-solstice-lughnasadh-lamas/

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It took only two weeks for the euphoria of having made a decision not to drive to wear off. I felt – and still feel – that it is an act of self-care and that I am being grown-up and realistic and responsible. These are all good things.

I am lucky enough to live in a city with both Uber and Lyft. I am unlucky enough to find it’s a total hassle to use these services. Twice I have been stranded, and most of the other times I have been anxious about being left on a street corner. It’s not a lot of fun.

I was going to call my reaction backlash, but it isn’t. It’s just the disappointment of waking up to reality. Backlash, according to the MacMillan dictionary, is “a strong, negative, and often angry reaction to something that has happened, especially a political or social change.”

We know of that backlash first-hand because people who had a vested interest in not exposing child abuse (especially the more violent, systematic versions of child abuse, like ritual abuse and government/military mind control) launched a sophisticated campaign to discredit survivors and their therapists. With enough stories placed in the media, the general public came to believe that such things just don’t happen…especially in their back yard.

There’s another, more personal, kind of backlash. It occurs when it seems that a cult member is about to escape. Attempts to intimidate them into staying increase – harassment, physical attacks, threats to attack people they care about, attempts to get them fired or evicted, etc. We are living evidence that these tactics don’t always work!

And then there is the internal backlash. When you do something that is loving toward yourself, or when you dare to fall in love or make a best friend or get a fantastic job, another part of you freaks out and tries to sabotage your accomplishment. There is a lot of internal chaos, self-criticism, and attempts at self-punishment. That is breaking the cult’s rules! And that is forbidden and dangerous and you must stop right now!

Everybody on the outside supported me, and I didn’t have much internal backlash. Occasionally a self-critical thought flowed into my mind. I was to blame. I should have worn sunglasses all my life. I should have taken the early signs of arthritis more seriously and started physical therapy earlier. And eaten better and exercised more and smarter. (Not that those things would have helped me drive longer. It’s just that when I think of one thing I did wrong, I get on a roll and think of all the other things that I could have or should have done and didn’t.) Realistically, wearing sunglasses every time I went outside might have bought me a year or so more of driving, but there still would have come a day when I would have had to give it up.

Those internal put-downs are few and faint. Mainly it is just a realization of what a hassle depending on strangers can be and how much longer it takes. Also, even though the Internet claims that it is no more expensive than owning a car, it sure seems that way. I haven’t gotten rid of the car yet, so, of course, I’m still paying insurance and, since the car is seventeen years old, there’s no depreciation to factor in.

Yesterday, however, there was a real positive side to not driving. My best friend took me to Trader Joe’s. He said, “You don’t have to stock up for a month, you know. We will go again.” I thanked him profusely, and he said, “This is what family is for.” I felt so loved!

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Upcoming Holidays

May
5/27 Memorial Day
June
6/9 – 6/10 Pentecost
6/16 Father’s Day
6/17 Full moon
6/20 Corpus Christi/Feast of the Body of Christ
6/21 Summer solstice
6/23 Midsummer’s Eve
6/24 St John’s Day
July
7/2 Total solar eclipse. Visible in parts of South America
7/4 Fourth of July/ US Independence Day
7/16 Full moon
July 16 – 17 Partial lunar eclipse. Visible in South America, Africa, most of Europe and Asia, Australia, and New Zealand.
7/25 St. James’ Day/Festival of the Horned God

Dates Important to Nazi and Neo-Nazi groups
6/6 D-Day: invasion of France in WW2
7/29 Hitler proclaimed leader of the Nazi party
(NOTE: Not all groups meet on Jewish holidays. Some groups also mark Candlemas, Beltane, Lammas, Halloween, the solstices and the equinoxes)

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Upcoming Holidays

May
5/12 Mothers’ Day
5/18 Full moon
5/27 Memorial Day
June
6/9 – 6/10 Pentecost
6/16 Father’s Day
6/17 Full moon
6/20 Corpus Christi/Feast of the Body of Christ
6/21 Summer solstice
6/23 Midsummer’s Eve
6/24 St John’s Day

Dates Important to Nazi and Neo-Nazi groups
4/30 Anniversary of Hitler’s death
5/1 – 5/2 Yom HaShoah (Holocaust Memorial Day)
5/7 – 5/8 Yom HaZikaron (Memorial Day, Day of Remembrance)
5/8 – 5/9 Yom HaAtzma’ut (Israeli Independence Day)
5/8 V-E Day (Victory in Europe, WW2)
5/18 Armed Forces Day (?)
(NOTE: Not all groups meet on Jewish holidays. Some groups also mark Candlemas, Beltane, Lammas, Halloween, the solstices and the equinoxes)

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Upcoming Holidays

May
5/27 Memorial Day
June
6/9 – 6/10 Pentecost
6/16 Father’s Day
6/17 Full moon
6/20 Corpus Christi/Feast of the Body of Christ
6/21 Summer solstice
6/23 Midsummer’s Eve
6/24 St John’s Day
July
7/2 Total solar eclipse. Visible in parts of South America
7/4 Fourth of July/ US Independence Day
7/16 Full moon
July 16 – 17 Partial lunar eclipse. Visible in South America, Africa, most of Europe and Asia, Australia, and New Zealand.
7/25 St. James’ Day/Festival of the Horned God

Dates Important to Nazi and Neo-Nazi groups
6/6 D-Day: invasion of France in WW2
7/29 Hitler proclaimed leader of the Nazi party
(NOTE: Not all groups meet on Jewish holidays. Some groups also mark Candlemas, Beltane, Lammas, Halloween, the solstices and the equinoxes)